These findings, combined with other patient features, may inform shared patient-clinician decision-making. At 2 years, the absolute risk reduction of recurrent stroke was greater (5.5% ) in patients with large shunt and ASA than for patients in the other 3 categories (1.0% for all).Ĭonclusions and Relevance Patients with both a large shunt and an ASA showed a substantially greater beneficial association with PFO closure than patients with large shunt alone, patients with small shunt and ASA, and patients with neither large shunt nor ASA. The reduction in hazard for recurrent stroke was greater for patients with both a large shunt and an ASA (aHR, 0.15 ) than for large shunt without ASA (aHR, 0.27 ), small shunt with ASA (aHR, 0.36 ), and small shunt without ASA (aHR, 0.68 ) (interaction P = .02). Treatment with PFO closure was associated with reduced risk for recurrent ischemic stroke (adjusted hazard ratio, 0.41 P < .001). Results A total of 121 recurrent ischemic strokes occurred in the pooled 3740 patients (mean age, 45 years 1682 female) during a median (IQR) follow-up of 57 (23.7-63.8) months. Main Outcomes and Measures Recurrent ischemic stroke. Analysis was completed in January 2022.Įxposures Transcatheter PFO closure plus antithrombotic therapy vs antithrombotic therapy alone, stratified into 4 groups based on the combination of 2 features: small vs large PFO shunt size and the presence or absence of an ASA. DOWNLOAD ENDNOTE 7 MAC SOFTWAREPatients in North America, Europe, Australia, Brazil, and South Korea with PFO-associated stroke were included. EndNote 20 is the reference management software that accelerates your research, by helping you save time, stay organized, collaborate with colleagues and, ultimately, get published. Objective To evaluate the association of PFO closure with stroke recurrence according to shunt size and/or the presence of an ASA.ĭesign, Setting, and Participants Pooled individual patient data from 6 randomized clinical trials conducted from February 2000 to October 2017 that compared PFO closure with medical therapy. DOWNLOAD ENDNOTE 7 MAC SOFTWARE DOWNLOADDownload EndNote zip folder to your desktop from the Information Solutions Software Download page. However, the distinctive associations of shunt size and ASA, alone and in combination, have not been completely delineated. 10 7 February 2019 Download the EndNote Referencing Style file For EndNote to display your references in your preferred style, it needs to know what that style is. Importance The Patent Foramen Ovale (PFO)–Associated Stroke Causal Likelihood classification system combines information regarding noncardiac patient features (vascular risk factors, infarct topography) and PFO features (shunt size and presence of atrial septal aneurysm ) to classify patients into 3 validated categories of responsiveness to treatment with PFO closure.
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